HL7 Terminology
2.1.0 - Publication

This page is part of the HL7 Terminology (v2.1.0: Release) based on FHIR R4. This is the current published version in it's permanent home (it will always be available at this URL). For a full list of available versions, see the Directory of published versions

: Substance Admin Substitution - XML Representation

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<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="v3-substanceAdminSubstitution"/>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en"><p><b>Properties</b></p><table class="grid"><tr><td><b>Code</b></td><td><b>URL</b></td><td><b>Description</b></td><td><b>Type</b></td></tr><tr><td>Specializes</td><td/><td>The child code is a more narrow version of the concept represented by the parent code.  I.e. Every child concept is also a valid parent concept.  Used to allow determination of subsumption.  Must be transitive, irreflexive, antisymmetric.</td><td>Coding</td></tr><tr><td>Generalizes</td><td/><td>Inverse of Specializes.  Only included as a derived relationship.</td><td>Coding</td></tr><tr><td>internalId</td><td>http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id</td><td>The internal identifier for the concept in the HL7 Access database repository.</td><td>code</td></tr><tr><td>notSelectable</td><td>http://hl7.org/fhir/concept-properties#notSelectable</td><td>Indicates that the code is abstract - only intended to be used as a selector for other concepts</td><td>boolean</td></tr><tr><td>status</td><td>http://hl7.org/fhir/concept-properties#status</td><td>Designation of a concept's state. Normally is not populated unless the state is retired.</td><td>code</td></tr></table><p>This code system http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution defines the following codes:</p><table class="codes"><tr><td><b>Lvl</b></td><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td><td><b>internalId</b></td><td><b>Not Selectable</b></td><td><b>status</b></td></tr><tr><td>1</td><td style="white-space:nowrap">_ActSubstanceAdminSubstitutionCode<a name="v3-substanceAdminSubstitution-_ActSubstanceAdminSubstitutionCode"> </a></td><td>ActSubstanceAdminSubstitutionCode</td><td>**Description:** Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.</td><td>21284</td><td>true</td><td>active</td></tr><tr><td>2</td><td style="white-space:nowrap">  E<a name="v3-substanceAdminSubstitution-E"> </a></td><td>equivalent</td><td>**Description:** Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.</td><td>23107</td><td/><td>active</td></tr><tr><td>3</td><td style="white-space:nowrap">    EC<a name="v3-substanceAdminSubstitution-EC"> </a></td><td>equivalent composition</td><td>**Description:** 

Substitution occurred or is permitted with another product that is a:

 *  pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
 *  pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration

*Examples:* 

 *  *Pharmaceutical alternative:* Erythromycin Ethylsuccinate for Erythromycin Stearate
 *  *Pharmaceutical equivalent:* Lisonpril for Zestril</td><td>23108</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      BC<a name="v3-substanceAdminSubstitution-BC"> </a></td><td>brand composition</td><td>**Description:** 

Substitution occurred or is permitted between equivalent Brands but not Generics

*Examples:* 

 *  Zestril for Prinivil
 *  Coumadin for Jantoven</td><td>23109</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      G<a name="v3-substanceAdminSubstitution-G"> </a></td><td>generic composition</td><td>**Description:** Substitution occurred or is permitted between equivalent Generics but not Brands

*Examples:* 

 *  Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)</td><td>16623</td><td/><td>active</td></tr><tr><td>3</td><td style="white-space:nowrap">    TE<a name="v3-substanceAdminSubstitution-TE"> </a></td><td>therapeutic alternative</td><td>**Description:** Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.

*Examples:* 

 *  ranitidine for Tagamet</td><td>16624</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      TB<a name="v3-substanceAdminSubstitution-TB"> </a></td><td>therapeutic brand</td><td>**Description:** Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics

&gt;

*Examples:* 

 *  Zantac for Tagamet</td><td>23105</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      TG<a name="v3-substanceAdminSubstitution-TG"> </a></td><td>therapeutic generic</td><td>**Description:** Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands

&gt;

*Examples:* 

 *  Ranitidine for cimetidine</td><td>23106</td><td/><td>active</td></tr><tr><td>2</td><td style="white-space:nowrap">  F<a name="v3-substanceAdminSubstitution-F"> </a></td><td>formulary</td><td>**Description:** This substitution was performed or is permitted based on formulary guidelines.</td><td>16625</td><td/><td>active</td></tr><tr><td>2</td><td style="white-space:nowrap">  N<a name="v3-substanceAdminSubstitution-N"> </a></td><td>none</td><td>No substitution occurred or is permitted.</td><td>16622</td><td/><td>active</td></tr></table></div>
  </text>
  <url
       value="http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.5.1070"/>
  </identifier>
  <version value="2.0.0"/>
  <name value="SubstanceAdminSubstitution"/>
  <title value="Substance Admin Substitution"/>
  <status value="active"/>
  <date value="2019-03-20"/>
  <publisher value="Health Level 7"/>
  <contact>
    <name value="Health Level Seven"/>
  </contact>
  <description
               value="Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided."/>
  <hierarchyMeaning value="is-a"/>
  <content value="complete"/>
  <property>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry">
      <valueCode value="antisymmetric"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity">
      <valueCode value="transitive"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity">
      <valueCode value="irreflexive"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable">
      <valueBoolean value="true"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind">
      <valueCode value="Specializes"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName">
      <valueString value="Generalizes"/>
    </extension>
    <code value="Specializes"/>
    <description
                 value="The child code is a more narrow version of the concept represented by the parent code.  I.e. Every child concept is also a valid parent concept.  Used to allow determination of subsumption.  Must be transitive, irreflexive, antisymmetric."/>
    <type value="Coding"/>
  </property>
  <property>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry">
      <valueCode value="antisymmetric"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity">
      <valueCode value="transitive"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity">
      <valueCode value="irreflexive"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable">
      <valueBoolean value="true"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind">
      <valueCode value="Generalizes"/>
    </extension>
    <extension
               url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName">
      <valueString value="Specializes"/>
    </extension>
    <code value="Generalizes"/>
    <description
                 value="Inverse of Specializes.  Only included as a derived relationship."/>
    <type value="Coding"/>
  </property>
  <property>
    <code value="internalId"/>
    <uri
         value="http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id"/>
    <description
                 value="The internal identifier for the concept in the HL7 Access database repository."/>
    <type value="code"/>
  </property>
  <property>
    <code value="notSelectable"/>
    <uri value="http://hl7.org/fhir/concept-properties#notSelectable"/>
    <description
                 value="Indicates that the code is abstract - only intended to be used as a selector for other concepts"/>
    <type value="boolean"/>
  </property>
  <property>
    <code value="status"/>
    <uri value="http://hl7.org/fhir/concept-properties#status"/>
    <description
                 value="Designation of a concept&#39;s state. Normally is not populated unless the state is retired."/>
    <type value="code"/>
  </property>
  <concept>
    <code value="_ActSubstanceAdminSubstitutionCode"/>
    <display value="ActSubstanceAdminSubstitutionCode"/>
    <definition
                value="**Description:** Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects."/>
    <property>
      <code value="notSelectable"/>
      <valueBoolean value="true"/>
    </property>
    <property>
      <code value="status"/>
      <valueCode value="active"/>
    </property>
    <property>
      <code value="internalId"/>
      <valueCode value="21284"/>
    </property>
    <concept>
      <code value="E"/>
      <display value="equivalent"/>
      <definition
                  value="**Description:** Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product."/>
      <property>
        <code value="status"/>
        <valueCode value="active"/>
      </property>
      <property>
        <code value="internalId"/>
        <valueCode value="23107"/>
      </property>
      <concept>
        <code value="EC"/>
        <display value="equivalent composition"/>
        <definition
                    value="**Description:** 

Substitution occurred or is permitted with another product that is a:

 *  pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
 *  pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration

*Examples:* 

 *  *Pharmaceutical alternative:* Erythromycin Ethylsuccinate for Erythromycin Stearate
 *  *Pharmaceutical equivalent:* Lisonpril for Zestril"/>
        <property>
          <code value="status"/>
          <valueCode value="active"/>
        </property>
        <property>
          <code value="internalId"/>
          <valueCode value="23108"/>
        </property>
        <concept>
          <code value="BC"/>
          <display value="brand composition"/>
          <definition
                      value="**Description:** 

Substitution occurred or is permitted between equivalent Brands but not Generics

*Examples:* 

 *  Zestril for Prinivil
 *  Coumadin for Jantoven"/>
          <property>
            <code value="status"/>
            <valueCode value="active"/>
          </property>
          <property>
            <code value="internalId"/>
            <valueCode value="23109"/>
          </property>
        </concept>
        <concept>
          <code value="G"/>
          <display value="generic composition"/>
          <definition
                      value="**Description:** Substitution occurred or is permitted between equivalent Generics but not Brands

*Examples:* 

 *  Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)"/>
          <property>
            <code value="status"/>
            <valueCode value="active"/>
          </property>
          <property>
            <code value="internalId"/>
            <valueCode value="16623"/>
          </property>
        </concept>
      </concept>
      <concept>
        <code value="TE"/>
        <display value="therapeutic alternative"/>
        <definition
                    value="**Description:** Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.

*Examples:* 

 *  ranitidine for Tagamet"/>
        <property>
          <code value="status"/>
          <valueCode value="active"/>
        </property>
        <property>
          <code value="internalId"/>
          <valueCode value="16624"/>
        </property>
        <concept>
          <code value="TB"/>
          <display value="therapeutic brand"/>
          <definition
                      value="**Description:** Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics

&gt;

*Examples:* 

 *  Zantac for Tagamet"/>
          <property>
            <code value="status"/>
            <valueCode value="active"/>
          </property>
          <property>
            <code value="internalId"/>
            <valueCode value="23105"/>
          </property>
        </concept>
        <concept>
          <code value="TG"/>
          <display value="therapeutic generic"/>
          <definition
                      value="**Description:** Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands

&gt;

*Examples:* 

 *  Ranitidine for cimetidine"/>
          <property>
            <code value="status"/>
            <valueCode value="active"/>
          </property>
          <property>
            <code value="internalId"/>
            <valueCode value="23106"/>
          </property>
        </concept>
      </concept>
    </concept>
    <concept>
      <code value="F"/>
      <display value="formulary"/>
      <definition
                  value="**Description:** This substitution was performed or is permitted based on formulary guidelines."/>
      <property>
        <code value="status"/>
        <valueCode value="active"/>
      </property>
      <property>
        <code value="internalId"/>
        <valueCode value="16625"/>
      </property>
    </concept>
    <concept>
      <code value="N"/>
      <display value="none"/>
      <definition value="No substitution occurred or is permitted."/>
      <property>
        <code value="status"/>
        <valueCode value="active"/>
      </property>
      <property>
        <code value="internalId"/>
        <valueCode value="16622"/>
      </property>
    </concept>
  </concept>
</CodeSystem>