@prefix fhir: . @prefix owl: . @prefix rdfs: . @prefix xsd: . # - resource ------------------------------------------------------------------- a fhir:CodeSystem ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "v3-substanceAdminSubstitution"] ; # fhir:language [ fhir:v "en"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "

Properties

This code system defines the following properties for its concepts

CodeURITypeDescription
SpecializesCodingThe child code is a more narrow version of the concept represented by the parent code. I.e. Every child concept is also a valid parent concept. Used to allow determination of subsumption. Must be transitive, irreflexive, antisymmetric.
GeneralizesCodingInverse of Specializes. Only included as a derived relationship.
internalIdhttp://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-idcodeThe internal identifier for the concept in the HL7 Access database repository.
notSelectablehttp://hl7.org/fhir/concept-properties#notSelectablebooleanIndicates that the code is abstract - only intended to be used as a selector for other concepts
statushttp://hl7.org/fhir/concept-properties#statuscodeDesignation of a concept's state. Normally is not populated unless the state is retired.

Concepts

This case-sensitive code system http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution defines the following codes in a Is-A heirarchy:

LvlCodeDisplayDefinitioninternalIdNot Selectablestatus
1_ActSubstanceAdminSubstitutionCode ActSubstanceAdminSubstitutionCode

Description: Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.

\n
21284trueactive
2  E equivalent

Description: Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.

\n
23107active
3    EC equivalent composition

Description:

\n

Substitution occurred or is permitted with another product that is a:

\n
    \n
  • pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
  • \n
  • pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration
  • \n
\n

Examples:

\n
    \n
  • Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
  • \n
  • Pharmaceutical equivalent: Lisonpril for Zestril
  • \n
\n
23108active
4      BC brand composition

Description:

\n

Substitution occurred or is permitted between equivalent Brands but not Generics

\n

Examples:

\n
    \n
  • Zestril for Prinivil
  • \n
  • Coumadin for Jantoven
  • \n
\n
23109active
4      G generic composition

Description: Substitution occurred or is permitted between equivalent Generics but not Brands

\n

Examples:

\n
    \n
  • Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
  • \n
\n
16623active
3    TE therapeutic alternative

Description: Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.

\n

Examples:

\n
    \n
  • ranitidine for Tagamet
  • \n
\n
16624active
4      TB therapeutic brand

Description: Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics

\n
\n
\n

Examples:

\n
    \n
  • Zantac for Tagamet
  • \n
\n
23105active
4      TG therapeutic generic

Description: Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands

\n
\n
\n

Examples:

\n
    \n
  • Ranitidine for cimetidine
  • \n
\n
23106active
2  F formulary

Description: This substitution was performed or is permitted based on formulary guidelines.

\n
16625active
2  N none

No substitution occurred or is permitted.

\n
16622active
" ] ; # fhir:url [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.5.1070" ] ] ) ; # fhir:version [ fhir:v "3.0.0"] ; # fhir:name [ fhir:v "SubstanceAdminSubstitution"] ; # fhir:title [ fhir:v "Substance Admin Substitution"] ; # fhir:status [ fhir:v "active"] ; # fhir:experimental [ fhir:v "false"^^xsd:boolean] ; # fhir:date [ fhir:v "2019-03-20"^^xsd:date] ; # fhir:publisher [ fhir:v "Health Level Seven International"] ; # fhir:contact ( [ fhir:telecom ( [ fhir:system [ fhir:v "url" ] ; fhir:value [ fhir:v "http://hl7.org" ] ] [ fhir:system [ fhir:v "email" ] ; fhir:value [ fhir:v "hq@HL7.org" ] ] ) ] ) ; # fhir:description [ fhir:v "Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided."] ; # fhir:copyright [ fhir:v "This material derives from the HL7 Terminology THO. THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license"] ; # fhir:caseSensitive [ fhir:v "true"^^xsd:boolean] ; # fhir:hierarchyMeaning [ fhir:v "is-a"] ; # fhir:content [ fhir:v "complete"] ; # fhir:property ( [ fhir:extension ( [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"^^xsd:anyURI ] ; fhir:value [ fhir:v "antisymmetric" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"^^xsd:anyURI ] ; fhir:value [ fhir:v "transitive" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"^^xsd:anyURI ] ; fhir:value [ fhir:v "irreflexive" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"^^xsd:anyURI ] ; fhir:value [ fhir:v "true"^^xsd:boolean ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"^^xsd:anyURI ] ; fhir:value [ fhir:v "Specializes" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"^^xsd:anyURI ] ; fhir:value [ fhir:v "Generalizes" ] ] ) ; fhir:code [ fhir:v "Specializes" ] ; fhir:description [ fhir:v "The child code is a more narrow version of the concept represented by the parent code. I.e. Every child concept is also a valid parent concept. Used to allow determination of subsumption. Must be transitive, irreflexive, antisymmetric." ] ; fhir:type [ fhir:v "Coding" ] ] [ fhir:extension ( [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"^^xsd:anyURI ] ; fhir:value [ fhir:v "antisymmetric" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"^^xsd:anyURI ] ; fhir:value [ fhir:v "transitive" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"^^xsd:anyURI ] ; fhir:value [ fhir:v "irreflexive" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"^^xsd:anyURI ] ; fhir:value [ fhir:v "true"^^xsd:boolean ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"^^xsd:anyURI ] ; fhir:value [ fhir:v "Generalizes" ] ] [ fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"^^xsd:anyURI ] ; fhir:value [ fhir:v "Specializes" ] ] ) ; fhir:code [ fhir:v "Generalizes" ] ; fhir:description [ fhir:v "Inverse of Specializes. Only included as a derived relationship." ] ; fhir:type [ fhir:v "Coding" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:uri [ fhir:v "http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id"^^xsd:anyURI ] ; fhir:description [ fhir:v "The internal identifier for the concept in the HL7 Access database repository." ] ; fhir:type [ fhir:v "code" ] ] [ fhir:code [ fhir:v "notSelectable" ] ; fhir:uri [ fhir:v "http://hl7.org/fhir/concept-properties#notSelectable"^^xsd:anyURI ] ; fhir:description [ fhir:v "Indicates that the code is abstract - only intended to be used as a selector for other concepts" ] ; fhir:type [ fhir:v "boolean" ] ] [ fhir:code [ fhir:v "status" ] ; fhir:uri [ fhir:v "http://hl7.org/fhir/concept-properties#status"^^xsd:anyURI ] ; fhir:description [ fhir:v "Designation of a concept's state. Normally is not populated unless the state is retired." ] ; fhir:type [ fhir:v "code" ] ] ) ; # fhir:concept ( [ fhir:code [ fhir:v "_ActSubstanceAdminSubstitutionCode" ] ; fhir:display [ fhir:v "ActSubstanceAdminSubstitutionCode" ] ; fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects." ] ; fhir:property ( [ fhir:code [ fhir:v "notSelectable" ] ; fhir:value [ fhir:v "true"^^xsd:boolean ] ] [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "21284" ] ] ) ; fhir:concept ( [ fhir:code [ fhir:v "E" ] ; fhir:display [ fhir:v "equivalent" ] ; fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product." ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "23107" ] ] ) ; fhir:concept ( [ fhir:code [ fhir:v "EC" ] ; fhir:display [ fhir:v "equivalent composition" ] ; fhir:definition [ fhir:v "**Description:** \r\n\r\nSubstitution occurred or is permitted with another product that is a:\r\n\r\n * pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester\r\n * pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration\r\n\r\n*Examples:* \r\n\r\n * *Pharmaceutical alternative:* Erythromycin Ethylsuccinate for Erythromycin Stearate\r\n * *Pharmaceutical equivalent:* Lisonpril for Zestril" ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "23108" ] ] ) ; fhir:concept ( [ fhir:code [ fhir:v "BC" ] ; fhir:display [ fhir:v "brand composition" ] ; fhir:definition [ fhir:v "**Description:** \r\n\r\nSubstitution occurred or is permitted between equivalent Brands but not Generics\r\n\r\n*Examples:* \r\n\r\n * Zestril for Prinivil\r\n * Coumadin for Jantoven" ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "23109" ] ] ) ] [ fhir:code [ fhir:v "G" ] ; fhir:display [ fhir:v "generic composition" ] ; fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted between equivalent Generics but not Brands\r\n\r\n*Examples:* \r\n\r\n * Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)" ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "16623" ] ] ) ] ) ] [ fhir:code [ fhir:v "TE" ] ; fhir:display [ fhir:v "therapeutic alternative" ] ; fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.\r\n\r\n*Examples:* \r\n\r\n * ranitidine for Tagamet" ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "16624" ] ] ) ; fhir:concept ( [ fhir:code [ fhir:v "TB" ] ; fhir:display [ fhir:v "therapeutic brand" ] ; fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics\r\n\r\n>\r\n\r\n*Examples:* \r\n\r\n * Zantac for Tagamet" ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "23105" ] ] ) ] [ fhir:code [ fhir:v "TG" ] ; fhir:display [ fhir:v "therapeutic generic" ] ; fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands\r\n\r\n>\r\n\r\n*Examples:* \r\n\r\n * Ranitidine for cimetidine" ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "23106" ] ] ) ] ) ] ) ] [ fhir:code [ fhir:v "F" ] ; fhir:display [ fhir:v "formulary" ] ; fhir:definition [ fhir:v "**Description:** This substitution was performed or is permitted based on formulary guidelines." ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "16625" ] ] ) ] [ fhir:code [ fhir:v "N" ] ; fhir:display [ fhir:v "none" ] ; fhir:definition [ fhir:v "No substitution occurred or is permitted." ] ; fhir:property ( [ fhir:code [ fhir:v "status" ] ; fhir:value [ fhir:v "active" ] ] [ fhir:code [ fhir:v "internalId" ] ; fhir:value [ fhir:v "16622" ] ] ) ] ) ] ) . # # -------------------------------------------------------------------------------------