<status value="active"/> <experimental value="false"/> <date value="2019-03-20"/> <publisher value="Health Level Seven International"/> <contact> <telecom> <system value="url"/> <value value="http://hl7.org"/> </telecom> <telecom> <system value="email"/> <value value="hq@HL7.org"/> </telecom> </contact> <description value="Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided."/> <copyright value="This material derives from the HL7 Terminology THO. THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license.html"/> <caseSensitive value="true"/> <hierarchyMeaning value="is-a"/> <content value="complete"/> <property> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"> <valueCode value="antisymmetric"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"> <valueCode value="transitive"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"> <valueCode value="irreflexive"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"> <valueBoolean value="true"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"> <valueCode value="Specializes"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"> <valueString value="Generalizes"/> </extension> <code value="Specializes"/> <description value="The child code is a more narrow version of the concept represented by the parent code. I.e. Every child concept is also a valid parent concept. Used to allow determination of subsumption. Must be transitive, irreflexive, antisymmetric."/> <type value="Coding"/> </property> <property> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"> <valueCode value="antisymmetric"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"> <valueCode value="transitive"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"> <valueCode value="irreflexive"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"> <valueBoolean value="true"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"> <valueCode value="Generalizes"/> </extension> <extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"> <valueString value="Specializes"/> </extension> <code value="Generalizes"/> <description value="Inverse of Specializes. Only included as a derived relationship."/> <type value="Coding"/> </property> <property> <code value="internalId"/> <uri value="http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id"/> <description value="The internal identifier for the concept in the HL7 Access database repository."/> <type value="code"/> </property> <property> <code value="notSelectable"/> <uri value="http://hl7.org/fhir/concept-properties#notSelectable"/> <description value="Indicates that the code is abstract - only intended to be used as a selector for other concepts"/> <type value="boolean"/> </property> <property> <code value="status"/> <uri value="http://hl7.org/fhir/concept-properties#status"/> <description value="Designation of a concept's state. Normally is not populated unless the state is retired."/> <type value="code"/> </property> <concept> <code value="_ActSubstanceAdminSubstitutionCode"/> <display value="ActSubstanceAdminSubstitutionCode"/> <definition value="Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects."/> <property> <code value="notSelectable"/> <valueBoolean value="true"/> </property> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="21284"/> </property> <concept> <code value="E"/> <display value="equivalent"/> <definition value="Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product."/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="23107"/> </property> <concept> <code value="EC"/> <display value="equivalent composition"/> <definition value="Substitution occurred or is permitted with another product that is a: * pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester * pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration *Examples:* * *Pharmaceutical alternative:* Erythromycin Ethylsuccinate for Erythromycin Stearate * *Pharmaceutical equivalent:* Lisonpril for Zestril"/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="23108"/> </property> <concept> <code value="BC"/> <display value="brand composition"/> <definition value="Substitution occurred or is permitted between equivalent Brands but not Generics *Examples:* * Zestril for Prinivil * Coumadin for Jantoven"/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="23109"/> </property> </concept> <concept> <code value="G"/> <display value="generic composition"/> <definition value="Substitution occurred or is permitted between equivalent Generics but not Brands *Examples:* * Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)"/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="16623"/> </property> </concept> </concept> <concept> <code value="TE"/> <display value="therapeutic alternative"/> <definition value="Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile. *Examples:* * ranitidine for Tagamet"/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="16624"/> </property> <concept> <code value="TB"/> <display value="therapeutic brand"/> <definition value="Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics > *Examples:* * Zantac for Tagamet"/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="23105"/> </property> </concept> <concept> <code value="TG"/> <display value="therapeutic generic"/> <definition value="Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands > *Examples:* * Ranitidine for cimetidine"/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="23106"/> </property> </concept> </concept> </concept> <concept> <code value="F"/> <display value="formulary"/> <definition value="This substitution was performed or is permitted based on formulary guidelines."/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="16625"/> </property> </concept> <concept> <code value="N"/> <display value="none"/> <definition value="No substitution occurred or is permitted."/> <property> <code value="status"/> <valueCode value="active"/> </property> <property> <code value="internalId"/> <valueCode value="16622"/> </property> </concept> </concept> </CodeSystem>

Generated Narrative: CodeSystem v3-substanceAdminSubstitution

Language: en

Properties

This code system defines the following properties for its concepts

Name

Code

URI

Type

Description

Specializes

Coding

The child code is a more narrow version of the concept represented by the parent code. I.e. Every child concept is also a valid parent concept. Used to allow determination of subsumption. Must be transitive, irreflexive, antisymmetric.

Generalizes

Coding

Inverse of Specializes. Only included as a derived relationship.

internalId

http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id

code

The internal identifier for the concept in the HL7 Access database repository.

Not Selectable

notSelectable

http://hl7.org/fhir/concept-properties#notSelectable

boolean

Indicates that the code is abstract - only intended to be used as a selector for other concepts

Status

status

http://hl7.org/fhir/concept-properties#status

code

Designation of a concept's state. Normally is not populated unless the state is retired.

Concepts

This case-sensitive code system http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution defines the following codes in a Is-A hierarchy:

Lvl	Code	Display	Definition	internalId	Not Selectable	Status
1	_ActSubstanceAdminSubstitutionCode	ActSubstanceAdminSubstitutionCode	Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.	21284	true	active
2	E	equivalent	Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.	23107		active
3	EC	equivalent composition	Substitution occurred or is permitted with another product that is a: pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration Examples: Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate Pharmaceutical equivalent: Lisonpril for Zestril	23108		active
4	BC	brand composition	Substitution occurred or is permitted between equivalent Brands but not Generics Examples: Zestril for Prinivil Coumadin for Jantoven	23109		active
4	G	generic composition	Substitution occurred or is permitted between equivalent Generics but not Brands Examples: Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)	16623		active
3	TE	therapeutic alternative	Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile. Examples: ranitidine for Tagamet	16624		active
4	TB	therapeutic brand	Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics Examples: Zantac for Tagamet	23105		active
4	TG	therapeutic generic	Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands Examples: Ranitidine for cimetidine	23106		active
2	F	formulary	This substitution was performed or is permitted based on formulary guidelines.	16625		active
2	N	none	No substitution occurred or is permitted.	16622		active