<status value="draft"/> <experimental value="false"/> <date value="2020-04-09T21:10:28+00:00"/> <publisher value="HL7 (FHIR Project)"/> <contact> <telecom> <system value="url"/> <value value="http://hl7.org/fhir"/> </telecom> <telecom> <system value="email"/> <value value="fhir@lists.hl7.org"/> </telecom> </contact> <description value="The subcomponent classification of quality of evidence rating systems."/> <caseSensitive value="true"/> <valueSet value="http://terminology.hl7.org/ValueSet/certainty-subcomponent-type"/> <content value="complete"/> <concept> <code value="RiskOfBias"/> <display value="Risk of bias"/> <definition value="methodologic concerns reducing internal validity."/> </concept> <concept> <code value="Inconsistency"/> <display value="Inconsistency"/> <definition value="concerns that findings are not similar enough to support certainty."/> </concept> <concept> <code value="Indirectness"/> <display value="Indirectness"/> <definition value="concerns reducing external validity."/> </concept> <concept> <code value="Imprecision"/> <display value="Imprecision"/> <definition value="fuzzy or wide variability."/> </concept> <concept> <code value="PublicationBias"/> <display value="Publication bias"/> <definition value="likelihood that what is published misrepresents what is available to publish."/> </concept> <concept> <code value="DoseResponseGradient"/> <display value="Dose response gradient"/> <definition value="higher certainty due to dose response relationship."/> </concept> <concept> <code value="PlausibleConfounding"/> <display value="Plausible confounding"/> <definition value="higher certainty due to risk of bias in opposite direction."/> </concept> <concept> <code value="LargeEffect"/> <display value="Large effect"/> <definition value="higher certainty due to large effect size."/> </concept> </CodeSystem>

This code system http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type defines the following codes:

Code	Display	Definition
RiskOfBias	Risk of bias	methodologic concerns reducing internal validity.
Inconsistency	Inconsistency	concerns that findings are not similar enough to support certainty.
Indirectness	Indirectness	concerns reducing external validity.
Imprecision	Imprecision	fuzzy or wide variability.
PublicationBias	Publication bias	likelihood that what is published misrepresents what is available to publish.
DoseResponseGradient	Dose response gradient	higher certainty due to dose response relationship.
PlausibleConfounding	Plausible confounding	higher certainty due to risk of bias in opposite direction.
LargeEffect	Large effect	higher certainty due to large effect size.